Cellulitis
- PMID: 31747177
- Bookshelf ID: NBK549770
Cellulitis
Excerpt
Cellulitis is a common bacterial skin infection, with over 14 million documented cases in the United States annually. This condition accounts for approximately $3.7 billion in ambulatory care costs and 650,000 hospitalizations annually. Cellulitis typically presents as a poorly demarcated, warm, erythematous area with associated edema and tenderness to palpation (see Image. Cellulitis).
Cellulitis is an acute bacterial infection causing inflammation of the deep dermis and surrounding subcutaneous tissue. The infection is without an abscess or purulent discharge. Beta-hemolytic streptococci most commonly cause cellulitis, typically group A streptococcus (Streptococcus pyogenes), followed by methicillin-sensitive Staphylococcus aureus (MSSA). Patients who are immunocompromised, colonized with methicillin-resistant Staphylococcus aureus (MRSA), bitten by animals, or have comorbidities such as diabetes mellitus may become infected with other bacteria. If the clinician correctly identifies and promptly treats cellulitis, the condition resolves with appropriate antibiotic treatment.
Copyright © 2025, StatPearls Publishing LLC.
Conflict of interest statement
Sections
References
-
- Raff AB, Kroshinsky D. Cellulitis: A Review. JAMA. 2016 Jul 19;316(3):325-37. - PubMed
-
- Bystritsky RJ. Cellulitis. Infect Dis Clin North Am. 2021 Mar;35(1):49-60. - PubMed
-
- Cranendonk DR, Lavrijsen APM, Prins JM, Wiersinga WJ. Cellulitis: current insights into pathophysiology and clinical management. Neth J Med. 2017 Nov;75(9):366-378. - PubMed
-
- Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF, Infectious Diseases Society of America Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011 Feb 01;52(3):e18-55. - PubMed
-
- Quirke M, Ayoub F, McCabe A, Boland F, Smith B, O'Sullivan R, Wakai A. Risk factors for nonpurulent leg cellulitis: a systematic review and meta-analysis. Br J Dermatol. 2017 Aug;177(2):382-394. - PubMed
Publication types
LinkOut - more resources
Full Text Sources