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Case Reports
. 2020 Mar:218:228-230.e1.
doi: 10.1016/j.jpeds.2019.10.042. Epub 2019 Nov 17.

Alagille Syndrome and Chronic Arthritis: An International Case Series

Giovanna Ferrara  1 , Teresa Giani  2 , Scott M Lieberman  3 , Courtney Kremer  3 , Sandy Hong  3 , Giuseppe Indolfi  4 , Grant Schulert  5 , Randy Q Cron  6 , Melissa L Mannion  6 , Sivia Lapidus  7 , Wineke Armbrust  8 , Emmanuel Gonzales  9 , Emmanuel Jacquemin  10 , Isabelle Koné-Paut  10 , Rolando Cimaz  11
Affiliations
Case Reports

Alagille Syndrome and Chronic Arthritis: An International Case Series

Giovanna Ferrara et al. J Pediatr. 2020 Mar.

Abstract

We describe 10 children with Alagille syndrome and inflammatory arthritis. In our centers, the prevalence of chronic arthritis in patients with Alagille syndrome is approximately 50 times higher compared with the general population. Arthritis was refractory to most treatment. Patients with Alagille syndrome should routinely be screened for musculoskeletal symptoms.

Keywords: alagille; inflammatory arthritis; juvenile idiopathic arthritis.

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