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Case Reports
. 2019 Oct;23(10):489-490.
doi: 10.5005/jp-journals-10071-23271.

Trientine-induced Rhabdomyolysis in an Adolescent with Wilson's Disease

Affiliations
Case Reports

Trientine-induced Rhabdomyolysis in an Adolescent with Wilson's Disease

Nagehan Aslan et al. Indian J Crit Care Med. 2019 Oct.

Abstract

Background: Drugs are very important in the etiology of nontraumatic rhabdomyolysis.

Case descriptions: A 16-year-old male patient with Wilson's disease was admitted for myoclonic contractions. Oral trientine was started for neurological problems and tremor on the hands due to D-penicillamine 1 month ago. Patient was oligoanuric, and his creatine kinase level was 15197 U/L. Rhabdomyolysis was associated with trientine, and trientine treatment was stopped. Hemodiafiltration was performed. The patient began to urinate on the 24th day.

Conclusion: This is the first pediatric patient with rhabdomyolysis induced by trientine. Drugs used should be questioned carefully in patients with rhabdomyolysis.

How to cite this article: Aslan N, Yavuz S, Yildizdas D, Horoz OO, Coban Y, Tumgor G, et al. Trientine-induced Rhabdomyolysis in an Adolescent with Wilson's Disease. Indian J Crit Care Med 2019;23(10):489-490.

Keywords: Continued renal replacement therapy; Rhabdomyolysis; Trientine.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

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CK levels measurements

References

    1. Vanholder R, Sever MS, Erek E, Lameire N. J Am Soc Nephrol. 2000;11:1553–1561. - PubMed
    1. Ward MM. Factors predictive of acute renal failure in rabdomyolisis. Arch İntern Med. 1998;148:1553–1557. - PubMed
    1. Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore) 2005;84:377–385. - PubMed
    1. Epstein O, Sherlock S. Triethylene tetramine dihydrochloride toxicity in primary biliary cirrhosis. Gastroenterology. 1980;78(6):1442–1445. - PubMed
    1. Lu J. Triethylenetetramine pharmacology and its clinical applications. Mol Cancer Ther. 2010;9:2458–2467. - PubMed

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