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. 2019 Oct;15(6):1381-1387.
doi: 10.5114/aoms.2018.80013. Epub 2018 Nov 29.

Effects of blood pressure goals on cardiovascular outcomes in hypertensive patients

Zonglei Du  1 , Weishi Bian  2 , Shanxia Wu  2 , Bingfeng Gao  2 , Yanfang Sun  2 , Zhenxing Kang  2 , Xianchao Zhang  3
Affiliations

Effects of blood pressure goals on cardiovascular outcomes in hypertensive patients

Zonglei Du et al. Arch Med Sci. 2019 Oct.

Abstract

Introduction: The aim of the study was to evaluate the effects of blood pressure (BP) goals on cardiovascular outcomes in hypertensive patients.

Material and methods: Primary hypertensive patients were retrospectively enrolled from outpatient clinics. The demographics, comorbidities, laboratory parameters and glomerular filtration rate (GFR) were collected. All participants were followed for 1 year. Cardiovascular outcomes included composite of all-cause mortality, non-fatal myocardial infarction, and non-fatal ischemic stroke/transient ischemic attack. Adverse event was defined as falling down and GFR decrease at follow-up.

Results: A total of 1226 patients were included. Based on therapeutic BP goals, participants were divided into low (< 130/80 mm Hg) and high (< 140/90 mm Hg) therapeutic goal groups and an uncontrolled hypertension (≥ 140/90 mm Hg) group. Compared to the low therapeutic goal group, patients in the uncontrolled group were older and more likely to be smokers, have longer duration of hypertension, diabetes mellitus, lower GFR and higher prevalent ischemic stroke (p < 0.05). Patients in the uncontrolled hypertension group had higher incidence of composite endpoints than low and high therapeutic goal groups. Two cases of falling down were observed in the low therapeutic goal group and no significant changes in GFR were observed. With adjustment for confounding factors, the uncontrolled hypertension group had higher risk of composite endpoints compared to low and high therapeutic goal groups, and these benefits were more prominent in the low versus high therapeutic goal group.

Conclusions: In hypertension patients, when compared to uncontrolled hypertension patients, low therapeutic BP goal is associated with better cardiovascular outcomes than high therapeutic BP goal.

Keywords: blood pressure; cardiovascular outcomes; therapeutic goal.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic study
See this image and copyright information in PMC

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