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Case Reports
. 2019 Sep 12;6(9):e00226.
doi: 10.14309/crj.0000000000000226. eCollection 2019 Sep.

Use of Tofacitinib for the Treatment of Arthritis Associated With Ulcerative Colitis

Wenfei Wang  1 , Noa Krugliak Cleveland  2 , Jacob Ollech  2 , David T Rubin  2
Affiliations
Case Reports

Use of Tofacitinib for the Treatment of Arthritis Associated With Ulcerative Colitis

Wenfei Wang et al. ACG Case Rep J. .

Abstract

Tofacitinib is a Janus kinase 1-3 inhibitor initially approved for the treatment of rheumatoid arthritis and now approved for the treatment of moderately to severely active ulcerative colitis (UC). We present the case of a patient with UC and seronegative inflammatory arthritis in whom arthritis progressed while on vedolizumab and was successfully treated with tofacitinib. This case provides insight into the use of tofacitinib for the treatment of UC and a concomitant extraintestinal manifestation of joint involvement.

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Figures

Figure 1.
Figure 1.
Right index finger and fifth digit synovitis while on vedolizumab and before tofacitinib treatment.
Figure 2.
Figure 2.
Resolution of joint swelling 8 weeks after tofacitinib treatment.
See this image and copyright information in PMC

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