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Comparative Study
. 2020 Jan;62(1):e12098.
doi: 10.1002/1348-9585.12098. Epub 2019 Nov 21.

Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men

Mi Xiang  1 , Huanhuan Hu  1 , Teppei Imai  2 , Akiko Nishihara  2 , Naoko Sasaki  3 , Takayuki Ogasawara  3 , Ai Hori  4 , Tohru Nakagawa  5 , Shuichiro Yamamoto  5 , Toru Honda  5 , Hiroko Okazaki  6 , Akihiko Uehara  7 , Makoto Yamamoto  8 , Toshiaki Miyamoto  9 , Takeshi Kochi  10 , Masafumi Eguchi  10 , Taizo Murakami  11 , Makiko Shimizu  11 , Kentaro Tomita  12 , Satsue Nagahama  13 , Akiko Nanri  1   14 , Maki Konishi  1 , Shamima Akter  1 , Keisuke Kuwahara  1   15 , Ikuko Kashino  1 , Miwa Yamaguchi  1 , Isamu Kabe  10 , Tetsuya Mizoue  1 , Naoki Kunugita  16 , Seitaro Dohi  6 ; Japan Epidemiology Collaboration on Occupational Health Study Group
Collaborators, Affiliations
Comparative Study

Association between anthropometric indices of obesity and risk of cardiovascular disease in Japanese men

Mi Xiang et al. J Occup Health. 2020 Jan.

Abstract

Objectives: We aimed to compare the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with risk of cardiovascular disease (CVD) among middle-aged working Japanese men.

Methods: A nested case-control study was performed among middle-aged male employees who underwent periodic health checkup. A total of 241 CVD cases were identified and matched individually on age, gender, and worksite with 1205 controls. Data on BMI, WC, WHtR, smoking, hypertension, diabetes, and dyslipidemia collected at 4 years before the event/index date were retrieved. Associations between BMI, WC, WHtR, and CVD risk were assessed by using conditional logistic regression models.

Results: The strength of the association of BMI, WC, and WHtR with CVD risk was similar. The smoking-adjusted odds ratio (95% confidence interval) for CVD was 1.60 (1.38-1.85), 1.53 (1.33-1.78), and 1.56 (1.35-1.81) for a 1 SD unit increase in BMI, WC, and WHtR respectively. After further adjustment for hypertension, diabetes, and dyslipidemia, these associations were attenuated but remained statistically significant.

Conclusions: Measures of general (BMI) and abdominal (WC and WHtR) obesity were similarly associated with CVD in middle-aged Japanese men.

Keywords: body mass index; cardiovascular disease; waist circumference; waist-to-height ratio.

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