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Book

PDE5 Inhibitors

Armaan Dhaliwal  1 , Mohit Gupta  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

PDE5 Inhibitors

Armaan Dhaliwal et al.
Free Books & Documents

Excerpt

The discovery of phosphodiesterase 5 inhibitors (PDE5 inhibitors) for causing the erection of the penis was accidental, noticed as a side effect while being administered to investigate their ability to treat hypertension and angina. Phosphodiesterase 5 Inhibitors (PDE5Is) are now widely used in the management of erectile dysfunction. This activity illustrates the indications, mechanism of action, administration, adverse drug reactions, contraindications, monitoring, and toxicity of PDE5 inhibitors. This activity also demonstrates the importance of an interprofessional team in the treatment of patients with erectile dysfunction, high altitude illness, lower urinary tract symptoms, angina, or pulmonary hypertension, using PDE5 inhibitors (i.e., sildenafil, tadalafil, vardenafil, etc.)

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Conflict of interest statement

Disclosure: Armaan Dhaliwal declares no relevant financial relationships with ineligible companies.

Disclosure: Mohit Gupta declares no relevant financial relationships with ineligible companies.

References

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