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Book

Pigmented Villonodular Synovitis

Christopher Fecek  1 , Kevin R. Carter  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Pigmented Villonodular Synovitis

Christopher Fecek et al.
Free Books & Documents

Excerpt

Pigmented villonodular synovitis (PVNS) refers to a subtype of tenosynovial giant cell tumors that diffusely affect the soft tissue lining of joints and tendons. PVNS most commonly affects the knee, hip, and ankle joints and is insidious in onset, with symptoms often being present for years before diagnosis. Furthermore, PVNS is more aggressive compared to the other major subtype of tenosynovial giant cell tumors, giant cell tumor of the tendon sheath (GCT-TS). According to a 1980 report, PVNS affects roughly 9.2 new people per million in the United States each year. Even after treatment, the recurrence rate of PVNS ranges from 14 to 55%.

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Conflict of interest statement

Disclosure: Christopher Fecek declares no relevant financial relationships with ineligible companies.

Disclosure: Kevin Carter declares no relevant financial relationships with ineligible companies.

References

    1. Burton TM, Ye X, Parker ED, Bancroft T, Healey J. Burden of Illness Associated with Tenosynovial Giant Cell Tumors. Clin Ther. 2018 Apr;40(4):593-602.e1. - PMC - PubMed
    1. Staals EL, Ferrari S, Donati DM, Palmerini E. Diffuse-type tenosynovial giant cell tumour: Current treatment concepts and future perspectives. Eur J Cancer. 2016 Aug;63:34-40. - PubMed
    1. West RB, Rubin BP, Miller MA, Subramanian S, Kaygusuz G, Montgomery K, Zhu S, Marinelli RJ, De Luca A, Downs-Kelly E, Goldblum JR, Corless CL, Brown PO, Gilks CB, Nielsen TO, Huntsman D, van de Rijn M. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):690-5. - PMC - PubMed
    1. Xie GP, Jiang N, Liang CX, Zeng JC, Chen ZY, Xu Q, Qi RZ, Chen YR, Yu B. Pigmented villonodular synovitis: a retrospective multicenter study of 237 cases. PLoS One. 2015;10(3):e0121451. - PMC - PubMed
    1. Mastboom MJL, Verspoor FGM, Verschoor AJ, Uittenbogaard D, Nemeth B, Mastboom WJB, Bovée JVMG, Dijkstra PDS, Schreuder HWB, Gelderblom H, Van de Sande MAJ, TGCT study group Higher incidence rates than previously known in tenosynovial giant cell tumors. Acta Orthop. 2017 Dec;88(6):688-694. - PMC - PubMed

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