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Book

Biochemistry, Merosin

Jennifer Witek  1 , Jose L. Flores  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Biochemistry, Merosin

Jennifer Witek et al.
Free Books & Documents

Excerpt

Merosin collectively is a term that refers to a group of laminins that share the alpha2 subunit encoded by the LAMA2 gene. Laminins are a family of high molecular weight glycoproteins that function as extracellular matrix components of the structural basement membrane. They are heterotrimers composed of homologous alpha, beta, and gamma polypeptide chains. Individually, these chains have a distinct organization of structural domains and can exhibit biological activities, including self-assembly and protein interaction. The alpha2 subunit is present in laminin 2 (merosin) and laminin 4 (s-merosin), two laminin types that play an integral role in skeletal muscle.

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Conflict of interest statement

Disclosure: Jennifer Witek declares no relevant financial relationships with ineligible companies.

Disclosure: Jose Flores declares no relevant financial relationships with ineligible companies.

References

    1. Wewer UM, Engvall E. Merosin/laminin-2 and muscular dystrophy. Neuromuscul Disord. 1996 Dec;6(6):409-18. - PubMed
    1. Yurchenco PD, McKee KK, Reinhard JR, Rüegg MA. Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies. Matrix Biol. 2018 Oct;71-72:174-187. - PMC - PubMed
    1. Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, Asplund A, Sjöstedt E, Lundberg E, Szigyarto CA, Skogs M, Takanen JO, Berling H, Tegel H, Mulder J, Nilsson P, Schwenk JM, Lindskog C, Danielsson F, Mardinoglu A, Sivertsson A, von Feilitzen K, Forsberg M, Zwahlen M, Olsson I, Navani S, Huss M, Nielsen J, Ponten F, Uhlén M. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 2014 Feb;13(2):397-406. - PMC - PubMed
    1. Villanova M, Malandrini A, Sabatelli P, Sewry CA, Toti P, Torelli S, Six J, Scarfó G, Palma L, Muntoni F, Squarzoni S, Tosi P, Maraldi NM, Guazzi GC. Localization of laminin alpha 2 chain in normal human central nervous system: an immunofluorescence and ultrastructural study. Acta Neuropathol. 1997 Dec;94(6):567-71. - PubMed
    1. Allamand V, Guicheney P. Merosin-deficient congenital muscular dystrophy, autosomal recessive (MDC1A, MIM#156225, LAMA2 gene coding for alpha2 chain of laminin). Eur J Hum Genet. 2002 Feb;10(2):91-4. - PubMed

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