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Review
. 2020 Jan;51(1):12-20.
doi: 10.1161/STROKEAHA.119.024151. Epub 2019 Nov 22.

Genetics of Cerebral Small Vessel Disease

Sandro Marini  1   2   3   4 , Christopher D Anderson  1   2   3   4 , Jonathan Rosand  1   2   3   4
Affiliations
Review

Genetics of Cerebral Small Vessel Disease

Sandro Marini et al. Stroke. 2020 Jan.
No abstract available

Keywords: amyloidosis; arterioloscleroses; cerebral small vessel diseases; genetics; genome-wide association studies; neuroimaging.

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Figures

Figure 1:
Figure 1:
Overview of pathological mechanisms that may be involved in cerebral small vessel disease (CSVD). Collagen dysfunction, distruption of vessel integrity, dissarangement of matrisome and increased permeabiliyt of blood brain barriers have been linked to genes and to macrosopic manifestations of CSVD, both in genetic epidemiology and studies on familial forms of the disease. The background color of genes and loci enlisted corresponds to at least one of the macroscopic manifestations of CSVD.
See this image and copyright information in PMC

References

    1. Pantoni L Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9:689–701. - PubMed
    1. Markus HS, Schmidt R. Genetics of Vascular Cognitive Impairment. Stroke; a journal of cerebral circulation. 2019;50:735–772. - PMC - PubMed
    1. Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. The Lancet Neurology. 2013;12:822–838. - PMC - PubMed
    1. Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2010;341:c3666. - PMC - PubMed
    1. Seshadri S, Beiser A, Pikula A, Himali JJ, Kelly-Hayes M, Debette S, et al. Parental occurrence of stroke and risk of stroke in their children: the Framingham study. Circulation. 2010;121:1304–1312. - PMC - PubMed

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