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Case Reports
. 2019 Nov 21;19(1):175.
doi: 10.1186/s12893-019-0638-x.

Case report: a camouflaged parathyroid carcinoma with initial misdiagnosis

Hongtao Cao  1 , Weibin Wang  2
Affiliations
Case Reports

Case report: a camouflaged parathyroid carcinoma with initial misdiagnosis

Hongtao Cao et al. BMC Surg. .

Abstract

Background: Parathyroid carcinoma is a rare malignancy with an increasing incidence. Most patients are characterized by the presence of severe primary hyperparathyroidism, especially hypercalcemia, while patients with normal level of serum calcium are extremely rare. Unfortunately, patients free of hypercalcemia are usually diagnosed at a later stage and suffer from a rather poor prognosis.

Case presentation: We describe a patient diagnosed with intrathyroidal normocalcemic parathyroid carcinoma, whose preoperative ultrasonography suggests that the tumor is located inside the thyroid gland and present without obvious clinical manifestations, which makes it more challenging for diagnosis.

Conclusions: Preoperative suspicion of malignancy is of great importance for advanced management while preoperative diagnosis is rather challenging with the limited contribution of imaging examinations. Any abnormality in serum level of calcium or parathormone may help to make an initial diagnosis especially when the level is extremely high. We introduce this case of initial misdiagnosis of an intrathyroidal parathyroid carcinoma, mimicking a suspicious thyroid nodule, to focus on the possible anomalous presentations of this rare condition and on its optimal management.

Keywords: Parathyroid adenocarcinoma,; asymptomatic,; intrathyroidal,; normocalcemic.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Ultrasonography of the parathyroid carcinoma
Fig. 2
Fig. 2
a & b pathology of the parathyroid carcinoma
See this image and copyright information in PMC

References

    1. Lee PK, Jarosek SL, Virnig BA, Evasovich M, Tuttle TM. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer. 2007;109(9):1736–1741. doi: 10.1002/cncr.22599. - DOI - PubMed
    1. Owen RP, Silver CE, Pellitteri PK, Shaha AR, Devaney KO, Werner JA, et al. Parathyroid carcinoma: a review. Head Neck. 2011;33(3):429–436. - PubMed
    1. Tejera Hernández AA, Gutiérrez Giner MI, Vega Benítez V, Fernández San Millan D, Hernández Hernández JR. Intrathyroidal parathyroid carcinoma. A case report and review of the literature. Endocrinología y Nutrición (English Edition) 2016;63(1):46–48. doi: 10.1016/j.endoen.2016.01.003. - DOI - PubMed
    1. Lloyd RV, Osamura RY, Klöppel G, Rosai J. WHO classification of tumors of endocrine organs. Lyon, France: World Health Organization; 2017.
    1. Cetani F, Pardi E, Marcocci C. Parathyroid carcinoma: a clinical and genetic perspective. Minerva Endocrinological. 2018;43(2):144–155. - PubMed

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