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Editorial
. 2019 Nov 4;5(4):225-230.
doi: 10.1016/S2055-6640(20)30032-7.

Treatment outcomes and factors associated with mortality among individuals with both TB and HIV in the antiretroviral era in Thailand

Sivaporn Gatechompol, Kamon Kawkitinarong, Gompol Suwanpimolkul, Pairaj Kateruttanakul  1 , Weerawat Manosuthi  2 , Jiratchaya Sophonphan  3 , Sasiwimol Ubolyam, Stephen J Kerr  3   4 , Anchalee Avihingsanon, Kiat Ruxrungtham  3   4
Affiliations
Editorial

Treatment outcomes and factors associated with mortality among individuals with both TB and HIV in the antiretroviral era in Thailand

Sivaporn Gatechompol et al. J Virus Erad. .

Abstract

Objective: This study aimed to compare treatment outcomes and factors associated with mortality in HIV-1-positive and HIV-1-negative individuals.

Methods: We conducted a cohort study between July 2008 and December 2016. Logistic regression was used to determine factors associated with outcomes and death after tuberculosis (TB) treatment.

Results: A total of 996 individuals with TB, 228 (22.9%) with HIV-1 co-infection and 770 (77.1%) who were HIV-1 negative were reviewed. The overall treatment success rate was 74.3%. The HIV-1-negative individuals with TB had significantly higher treatment success rates (77.2% vs 64.5%, P < 0.001). Using logistic regression analysis, age >50 years (adjusted odds ratio [aOR] 3.89, 95% confidence interval [CI] 2.24-6.76; P < 0.001), body weight ≤45 kg (aOR 2.19, 95% CI 1.14-4.19; P = 0.02) and HIV-1-positive status (aOR 3.31, 95% CI 1.84-5.91; P < 0.001) were independently associated with death during TB treatment. Among HIV-1-positive individuals, not undergoing antiretroviral therapy (ART), having diabetes and a CD4 T cell count of <50 cells/mm3 were significantly associated with death.

Conclusion: Individuals who had both TB and HIV-1 in Thailand had lower TB treatment success and higher mortality rates compared with individuals with TB without HIV-1. Strategies to improve ART uptake and to reduce risk of developing active TB among individuals with advanced HIV-1 infection should be scaled up.

Keywords: TB/HIV; antiretroviral therapy; risk factors; treatment outcome.

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Figures

Figure 1.
Figure 1.
Overview of cases included in the analysis
See this image and copyright information in PMC

References

    1. WHO Global tuberculosis report 2018. Available at: www.who.int/tb/publications/global_report/en/ ( accessed May 2019).
    1. Teeraananchai S, Chaivooth S, Kerr SJ et al. . Life expectancy after initiation of combination antiretroviral therapy in Thailand. Antivir Ther 2017; 22: 393– 402. - PubMed
    1. Kwan CK, Ernst JD. HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev 2011; 24: 351– 376. - PMC - PubMed
    1. WHO Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. Second edition 2016. Available at: www.who.int/hiv/pub/arv/arv-2016/en/ ( accessed May 2019). - PubMed
    1. WHO Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach: 2010 revision. Available at: www.who.int/hiv/pub/arv/adult2010/en/ ( accessed May 2019). - PubMed

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