Multicenter Study

. 2020 Apr 7;221(9):1488-1493.

doi: 10.1093/infdis/jiz623.

Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France

Catharina J Alberts¹, Isabelle Heard^{2

3}, Ana Canestri⁴, Lucie Marchand⁵, Jean-François Fléjou^{6

7}, Lionel Piroth^{8

9}, Tristan Ferry¹⁰, Jean-Michel Didelot¹¹, Laurent Siproudhis^{12

13

14}, Sébastien Henno¹⁵, Isabelle Poizot-Martin^{16

17}, Teresa M Darragh¹⁸, Gary M Clifford¹, Jean-Damien Combes¹, Isabelle Etienney¹⁹; ANRS EP57 APACHES Study group

Collaborators, Affiliations

Collaborators

ANRS EP57 APACHES Study group:
C Arvieux, A Canestri, G M Clifford, J D Combes, V Costes-Martineau, J Del Grande, J M Didelot, I Etienney, M Falguières, T Ferry, H Fischer, J F Flejou, I Heard, S Henno, N Hoyau, M Landon, H Laude, F Le Breton, A C Lesage, A Lion, G Maincent, L Marchand, H Njatonirina, O Patey, V Petrov Sanchez, V Pialoux, L Piroth, I Poizot-Martin, O Zaegel-Faucher, E Ressiot, S Radenne, J Reynes, L Siproudhis, C Tamalet, P Tattevin

Affiliations

¹ International Agency for Research on Cancer, Lyon, France.
² Centre National de Référence des HPV, Institut Pasteur, Paris, France.
³ Hôpital Tenon, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
⁴ Service des Maladies Infectieuses et Tropicales, Hôpital Tenon, AP-HP, Paris, France.
⁵ ANRS (France Recherche Nord et Sud Sida-HIV et Hépatites), Paris, France.
⁶ Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), AP-HP, Paris, France.
⁷ Faculté de Médecine Sorbonne Université, Paris, France.
⁸ Département d'Infectiologie, Centre Hospitalier Universitaire (CHU) de Dijon, Dijon, France.
⁹ Institut National de la Sante et de la Recherche Medicale (INSERM) Centre d'Investigation Clinique (CIC) 1432, Université de Bourgogne, Dijon, France.
¹⁰ Département d'Infectiologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
¹¹ Département d'Hépato-Gastroentérologie, CHU Saint Eloi et Université de Montpellier, Montpellier, France.
¹² Department of Gastroenterology, University Hospital of Rennes, Pontchaillou, Rennes, France.
¹³ INSERM U1241, University of Rennes 1, Rennes, France.
¹⁴ INPHY CIC 1414 University Hospital of Rennes, Pontchaillou, Rennes, France.
¹⁵ Service d'Anatomie et Cytologie Pathologiques, CHU Pontchaillou, Rennes, France.
¹⁶ Service d'Immuno-Hématologie Clinique, Université Aix Marseille, APHM Sainte-Marguerite, Marseille, France.
¹⁷ INSERM U912 (Sciences économiques et sociales de la santé et traitement de l'information médicale - SESSTIM), Marseille, France.
¹⁸ Department of Pathology, University of California San Francisco, San Francisco, California, USA.
¹⁹ Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.

PMID: 31754686
DOI: 10.1093/infdis/jiz623

Free article

Multicenter Study

Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France

Catharina J Alberts et al. J Infect Dis. 2020.

Free article

. 2020 Apr 7;221(9):1488-1493.

doi: 10.1093/infdis/jiz623.

Authors

Collaborators

ANRS EP57 APACHES Study group:
C Arvieux, A Canestri, G M Clifford, J D Combes, V Costes-Martineau, J Del Grande, J M Didelot, I Etienney, M Falguières, T Ferry, H Fischer, J F Flejou, I Heard, S Henno, N Hoyau, M Landon, H Laude, F Le Breton, A C Lesage, A Lion, G Maincent, L Marchand, H Njatonirina, O Patey, V Petrov Sanchez, V Pialoux, L Piroth, I Poizot-Martin, O Zaegel-Faucher, E Ressiot, S Radenne, J Reynes, L Siproudhis, C Tamalet, P Tattevin

Affiliations

¹ International Agency for Research on Cancer, Lyon, France.
² Centre National de Référence des HPV, Institut Pasteur, Paris, France.
³ Hôpital Tenon, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
⁴ Service des Maladies Infectieuses et Tropicales, Hôpital Tenon, AP-HP, Paris, France.
⁵ ANRS (France Recherche Nord et Sud Sida-HIV et Hépatites), Paris, France.
⁶ Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), AP-HP, Paris, France.
⁷ Faculté de Médecine Sorbonne Université, Paris, France.
⁸ Département d'Infectiologie, Centre Hospitalier Universitaire (CHU) de Dijon, Dijon, France.
⁹ Institut National de la Sante et de la Recherche Medicale (INSERM) Centre d'Investigation Clinique (CIC) 1432, Université de Bourgogne, Dijon, France.
¹⁰ Département d'Infectiologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
¹¹ Département d'Hépato-Gastroentérologie, CHU Saint Eloi et Université de Montpellier, Montpellier, France.
¹² Department of Gastroenterology, University Hospital of Rennes, Pontchaillou, Rennes, France.
¹³ INSERM U1241, University of Rennes 1, Rennes, France.
¹⁴ INPHY CIC 1414 University Hospital of Rennes, Pontchaillou, Rennes, France.
¹⁵ Service d'Anatomie et Cytologie Pathologiques, CHU Pontchaillou, Rennes, France.
¹⁶ Service d'Immuno-Hématologie Clinique, Université Aix Marseille, APHM Sainte-Marguerite, Marseille, France.
¹⁷ INSERM U912 (Sciences économiques et sociales de la santé et traitement de l'information médicale - SESSTIM), Marseille, France.
¹⁸ Department of Pathology, University of California San Francisco, San Francisco, California, USA.
¹⁹ Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.

PMID: 31754686
DOI: 10.1093/infdis/jiz623

Abstract

Background: Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM).

Methods: We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018).

Results: Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months).

Conclusions: In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.

Keywords: anal HPV infection; human immunodeficiency virus; incidence; men who have sex with men.

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Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France

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Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France

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