Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 3;59(6):2328-2332.
doi: 10.1002/anie.201913743. Epub 2019 Dec 27.

Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes

Jun He  1 , Yuhang Xue  1 , Bo Han  1 , Chunzhu Zhang  1 , You Wang  1 , Shaolin Zhu  1
Affiliations

Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes

Jun He et al. Angew Chem Int Ed Engl. .

Abstract

Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis.

Keywords: alkenes; asymmetric catalysis; carboamination; nickel; synthetic methods.

PubMed Disclaimer

References

    1. For selected reviews, see:
    1. W. S. Knowles, Angew. Chem. Int. Ed. 2002, 41, 1998;
    1. Angew. Chem. 2002, 114, 2096;
    1. R. Noyori, Angew. Chem. Int. Ed. 2002, 41, 2008;
    1. Angew. Chem. 2002, 114, 2108.

LinkOut - more resources