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. 2019 Dec 5;55(98):14777-14780.
doi: 10.1039/c9cc08518a.

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Francesca Nardelli  1 , Michela Ghitti  1 , Giacomo Quilici  1 , Alessandro Gori  2 , Qingqiong Luo  3 , Andrea Berardi  1 , Angelina Sacchi  1 , Matteo Monieri  1 , Greta Bergamaschi  2 , Wolfgang Bermel  4 , Fuxiang Chen  3 , Angelo Corti  5 , Flavio Curnis  1 , Giovanna Musco  1
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A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Francesca Nardelli et al. Chem Commun (Camb). .

Abstract

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.

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