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. 2019 Nov 22;14(11):e0225036.
doi: 10.1371/journal.pone.0225036. eCollection 2019.

Periodontal disease: Repercussions in pregnant woman and newborn health-A cohort study

Marina Guim Otsuka Padovan Figueiredo  1 , Stefanie Yaemi Takita  1 , Bianca Maria Ramos Dourado  1 , Helderjan de Souza Mendes  2 , Erick Olsen Terakado  3 , Hélio Rubens de Carvalho Nunes  1 , Cátia Regina Branco da Fonseca  1
Affiliations

Periodontal disease: Repercussions in pregnant woman and newborn health-A cohort study

Marina Guim Otsuka Padovan Figueiredo et al. PLoS One. .

Abstract

Objective: To investigate the repercussion of periodontal disease (PD) in the pregnant woman health and the complications during pregnancy and delivery, as well as negative outcomes for the newborn (as infections, prematurity, low birth weight and fetal growth restriction).

Method: Retrospective cohort study, based on medical records of 142 pregnant women assisted at a prenatal service of usual risk between 2012-2014, with a dental evaluation for PD. Maternal variables, along with labor and newborn variables, were analyzed. The newborns were stratified into two groups: offspring of mothers with PD (subdivided into Severe Periodontal Disease-SPD) and offspring of mothers without PD. Each outcome was adjusted by a multiple logistic regression model, with significance for p-value <0.05, considering all potential confounding factors.

Results: Among women diagnosed with SPD, the odds ratio for vulvovaginitis was 3.45 times greater (OR = 3.45, p-value = 0.050) and 5.59 times higher for premature rupture of membranes (OR = 5.59; p-value = 0.017). For neonates, the chance of fetal growth restriction was 11.53 times higher for pregnant women with SPD (OR = 11.53, p = 0.041).

Conclusion: The periodontal disease increased the chance of neonatal and maternal negative outcomes, being the fetal growth restriction, vulvovaginitis and premature rupture of the membrane (PROM) the main results driven by the presence of Severe Periodontal Disease.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of data collection and inclusion of pregnant women.
* PD = periodontal disease.
Fig 2
Fig 2. Distribution of level of education of pregnant women in the study.
See this image and copyright information in PMC

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