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Review
. 2019 Nov 20;7(12):583.
doi: 10.3390/microorganisms7120583.

The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story

Hongyu Cheng  1 , Xiong Guan  1 , Dekun Chen  1 , Wentao Ma  1
Affiliations
Review

The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story

Hongyu Cheng et al. Microorganisms. .

Abstract

The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota. Gut microbiota has been demonstrated to interact with immune cells and to modulate specific signaling pathways involving both innate and adaptive immune processes. Accumulated evidence suggests that the imbalance of Th17 and Treg cells is associated with the development of many diseases. Herein, we emphatically present recent findings to show how specific gut microbiota organisms and metabolites shape the balance of Th17 and Treg cells. We also discuss the therapeutic potential of fecal microbiota transplantation (FMT) in diseases caused by the imbalance of Th17 and Treg cells.

Keywords: Th17; Treg; balance; gut microbiota; metabolites.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Roles of the microbiota in the balance of Th17 and Treg.
Figure 2
Figure 2
Metabolites of gut microbiota affect the balance of Th17 and Treg.
See this image and copyright information in PMC

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