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. 1979 Dec;9(5-6):516-20.
doi: 10.1007/BF01968121.

The antipyretic effect of UP 517-03 in the rabbit

F Hertz, M M Chevrier, G Dumeur, J M Lwoff

The antipyretic effect of UP 517-03 in the rabbit

F Hertz et al. Agents Actions. 1979 Dec.

Abstract

The antipyretic effect of UP 517-03 was studied in rabbits, provided with a cannula in the lateral cerebral ventricle. Given orally as a curative treatment, UP 517-03 can abolish hyperthermic reactions induced by intracerebroventricular injection of sodium arachidonate or bacterial endotoxin. A comparison with acetylsalicylic acid and indomethacin is given. UP 517-03 does not modify the temperature of normothermic rabbits. These results suggests that the antipyretic action of UP 517-03 can be explained by an effect of this substance on the metabolism of arachidonic acid in brain.

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References

    1. Pharmacol Rev. 1974 Mar;26(1):33-67 - PubMed
    1. Eur J Pharmacol. 1977 Aug 1;44(3):197-204 - PubMed
    1. Arch Int Pharmacodyn Ther. 1972 May;197(1):31-6 - PubMed
    1. J Infect Dis. 1975 Aug;132(2):157-64 - PubMed
    1. J Physiol. 1975 Jun;248(1):26P-27P - PubMed