Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;104(1):1-14.
doi: 10.1016/j.mcna.2019.08.005.

Approach to Patients with Eosinophilia

Fei Li Kuang  1
Affiliations
Review

Approach to Patients with Eosinophilia

Fei Li Kuang. Med Clin North Am. 2020 Jan.

Abstract

Physicians may encounter blood or tissue eosinophilia through a routine complete blood count with differential or a tissue pathology report. In this article, the basic biology of eosinophils is reviewed and definitions of blood eosinophilia, as well as the challenges of defining tissue eosinophilia, are discussed. Conditions associated with eosinophilia are briefly discussed as well as a general approach to evaluating eosinophilia. Future challenges include determining which eosinophil-associated diseases benefit from eosinophil-targeted therapy and identifying biomarkers for disease activity and diagnosis.

Keywords: Biologics; Corticosteroids; Eosinophil; Eosinophil granule proteins; Hypereosinophilia; IL-5.

PubMed Disclaimer

References

    1. Sakula A Charcot-Leyden crystals and Curschmann spirals in asthmatic sputum. Thorax. 1986. July;41(7):503–7. - PMC - PubMed
    1. Davoine F, Lacy P. Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity. Front Immunol. 2014. November 10;5:570. - PMC - PubMed
    1. Melo RCN, Weller PF. Unraveling the complexity of lipid body organelles in human eosinophils. J Leukoc Biol. 2014. November;96(5):703–12. - PMC - PubMed
    1. Spencer LA, Bonjour K, Melo RCN, Weller PF. Eosinophil secretion of granule-derived cytokines. Front Immunol. 2014. October 27;5:496. - PMC - PubMed
    1. Ueki S, Tokunaga T, Melo RCN, Saito H, Honda K, Fukuchi M, et al. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Blood. 2018. November 15;132(20):2183–7. - PMC - PubMed