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Review
. 2020 Feb;47(1):111-118.
doi: 10.1016/j.ucl.2019.09.013.

Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Carissa E Chu  1 , Sima P Porten  1 , Gary D Grossfeld  2 , Maxwell V Meng  3
Affiliations
Review

Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Carissa E Chu et al. Urol Clin North Am. 2020 Feb.

Abstract

Due to significant risks of cancer recurrence and progression, and limited options after intravesical Bacillus Calmette Guerin (BCG) therapy, there is a critical unmet need to identify novel treatments for those patients with BCG-unresponsive bladder cancer. There is active investigation of immunotherapies which provide both biologic and clinical rationales for indoleamine-2,3- dioxygenase inhibitors in salvage therapy for non-muscle invasive bladder cancer.

Keywords: BCG-unresponsive; IDO inhibitors; Non–muscle invasive bladder cancer.

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