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Review
. 2019:1189:179-210.
doi: 10.1007/978-981-32-9717-3_7.

Control of Regulatory T Cells by Co-signal Molecules

James Badger Wing  1 , Christopher Tay  1 , Shimon Sakaguchi  2   3
Affiliations
Review

Control of Regulatory T Cells by Co-signal Molecules

James Badger Wing et al. Adv Exp Med Biol. 2019.

Abstract

Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.

Keywords: CD27; CD28; CD30; CTLA-4; DR3; GITR; ICOS; OX40; PD-1; TIGIT; TNFR2; Tim-3; Tregs.

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