Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec;593(24):3609-3622.
doi: 10.1002/1873-3468.13691. Epub 2019 Dec 9.

State-of-the-art human adenovirus vectorology for therapeutic approaches

Jian Gao  1 , Kemal Mese  1 , Oskar Bunz  1 , Anja Ehrhardt  1
Affiliations
Free article
Review

State-of-the-art human adenovirus vectorology for therapeutic approaches

Jian Gao et al. FEBS Lett. 2019 Dec.
Free article

Abstract

Human adenoviruses (Ads) have long been studied in the basic virology field and are exploited as vectors for gene therapy, vaccination, and oncolytic therapy. Ads are usually mild pathogens, but they can cause severe infections and symptoms in immunocompromised individuals. Ads show a large natural diversity and a broad spectrum of hosts. However, replication-competent and replication-deficient Ad vectors with therapeutic applications have been built mainly starting from human Ad type 5, because generating vectors from other human and animal Ads has proven challenging. This review provides an updated overview of vectors that are not derived from human Ad type 5. We discuss genetic engineering techniques for getting access to the natural diversity of human Ads and for vectorization of alternative Ad types. A catalogue of currently available vectorized human Ads and translational applications thereof is also compiled. We conclude with a perspective on Ad vectorology that looks into the future of Ad vectors in translational medicine.

Keywords: adenoviral vector; adenovirus; assembly; cloning; gene therapy; genome engineering; oncolytic virus; vaccination; vector production; virus type.

PubMed Disclaimer

References

    1. Madisch I, Harste G, Pommer H and Heim A (2005) Phylogenetic analysis of the main neutralization and hemagglutination determinants of all human adenovirus prototypes as a basis for molecular classification and taxonomy. J Virol 79, 15265-15276.
    1. Ronchi A, Doern C, Brock E, Pugni L and Sanchez PJ (2014) Neonatal adenoviral infection: a seventeen year experience and review of the literature. J Pediatr 164, 529.e1-535.e4.
    1. Mena KD and Gerba CP (2009) Waterborne adenovirus. Rev Environ Contam Toxicol 198, 133-167.
    1. Rosenlew M, Stenvik M, Roivainen M, Jarvenpaa AL and Hovi T (1999) A population-based prospective survey of newborn infants with suspected systemic infection: occurrence of sporadic enterovirus and adenovirus infections. J Clin Virol 12, 211-219.
    1. Wensley DF and Baldwin VJ (1985) Respiratory distress in the second week of life. J Pediatr 106, 326-331.

Publication types

LinkOut - more resources