Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Dec 1;117(6):e635-e639.
doi: 10.5546/aap.2019.e635.

[Congenital Zika syndrome in Argentina: case series study]

[Article in Spanish]
Analía Pastrana  1 , María Albarracín  2 , Marina Hoffmann  3 , Gabriela Delturco  3 , René López  3 , Ramiro Gil  3 , Ariel Guzmán  3 , Mario Del Barco  2 , Alberto Espeche  3
Affiliations
Free article
Case Reports

[Congenital Zika syndrome in Argentina: case series study]

[Article in Spanish]
Analía Pastrana et al. Arch Argent Pediatr. .
Free article

Abstract

In 2015, there was an increase in the incidence of congenital microcephaly in newborns in Brazil. Months later, the causal relationship between Zika virus and these findings was discovered. In Argentina, during the first outbreak there were 5 cases of congenital Zika syndrome reported. In 2017, there was a new outbreak which involved Salta province. We describe 2 patients with autochthonous congenital Zika syndrome: one of the babies with severe congenital microcephaly with lissencephaly, calcifications and ventriculomegaly; and another baby with postnatal microcephaly with asymmetric polymicrogyria, calcifications and delayed myelination. The real impact of this disease is still uncertain, so it is necessary an adequate multidisciplinary monitoring of patients exposed to Zika virus to better understand the infection and its natural history.

Keywords: Zika virus; congenital Zika syndrome; microcephaly.

Plain language summary

En 2015, se observó un incremento en la incidencia de microcefalia congénita en recién nacidos en Brasil. Meses más tarde, se descubrió la relación causal entre el virus del Zika y estos hallazgos. Durante el primer brote en la Argentina, se reportaron 5 casos de síndrome de Zika congénito. En 2017, hubo un nuevo brote que involucró la provincia de Salta. En este trabajo, se presentan 2 casos clínicos con síndrome de Zika congénito autóctonos: una paciente con microcefalia congénita grave con lisencefalia, calcificaciones corticosubcorticales y ventriculomegalia y otra paciente con microcefalia posnatal con polimicrogiria asimétrica y calcificaciones subcorticales y retraso en la mielinización. El real impacto de esta enfermedad aún es incierto; es necesario un adecuado seguimiento multidisciplinario de los pacientes expuestos al virus del Zika para comprender mejor la infección y su historia natural.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

References

    1. Baud D, Gubler D, Schaub B, Lanteri M, et al. An update on Zika virus infection. Lancet. 2017; 390(10107):2099-109.
    1. Tellechea A, Barbero P, Bidondo M, Groisman B, et al. Pautas de detección y seguimiento de niños y niñas nacidos con microcefalia y/o anomalias cerebrales en el contexto de la emergencia por el virus Zika. Buenos Aires: RENAC-Ar/Unicef; 2017. [Acceso: julio de 2019]. Disponible en: http://www.anlis.gov.ar/cenagem/wpcontent/uploads/2017/07/PAUTAS-MICROCE....
    1. Ribeiro BN, Muniz BC, Gasparetto E, Ventura N, et al. Congenital Zika syndrome and neuroimaginig findings: what do we know so far? Radiol Bras. 2017; 50(5):314-22.
    1. Tellechea A, Luppo V, Morales M, Groisman B, et al. Surveillance of microcephaly and selected brain anomalies in Argentina: Relationship with Zika virus and other congenital infections. Birth Defects Res. 2018; 110(12):1016-26.
    1. Saad T, PennaeCosta A, De Góes FV, De Freitas M, et al. Neurological manifestations of congenital Zika virus infection. Childs Nerv Syst. 2018; 34(1):73-8.

Publication types

Supplementary concepts

LinkOut - more resources