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. 2020 Mar;26(3):562-567.
doi: 10.1016/j.bbmt.2019.11.020. Epub 2019 Nov 20.

Reliability and Validity of the Modified 7-Day Lee Chronic Graft-versus-Host Disease Symptom Scale

Christopher Teh  1 , Lynn Onstad  1 , Stephanie J Lee  2
Affiliations

Reliability and Validity of the Modified 7-Day Lee Chronic Graft-versus-Host Disease Symptom Scale

Christopher Teh et al. Biol Blood Marrow Transplant. 2020 Mar.

Abstract

Chronic graft-versus-host disease (cGVHD) adversely affects patient quality of life, functional status, and survival after allogenic hematopoietic cell transplantation. The Lee Symptom Scale is a 30-item scale developed to measure the symptoms of cGVHD. Although the original 30-item scale uses a 1-month recall period, we tested the reliability and validity of a 28-item scale (deleting 2 items based on supportive care needs rather than symptoms) with a 7-day recall period, a format that is more appropriate for use in clinical trials. Results show the modified 7-day scale is reliable and valid in the modern era and may be used to assess the symptom burden of cGVHD in clinical trials. Using the distribution method, a 5- to 6-point difference (half a standard deviation) is considered clinically meaningful.

Keywords: chronic graft-versus-host disease; patient-reported outcomes; quality of life; survey; symptoms.

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Conflict of interest statement

Conflict of interest: None

References

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