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Review
. 2020 Jun:56:23-27.
doi: 10.1016/j.cbpa.2019.10.004. Epub 2019 Nov 20.

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

Sherri A McFarland  1 , Arkady Mandel  2 , Roger Dumoulin-White  2 , Gilles Gasser  3
Affiliations
Review

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

Sherri A McFarland et al. Curr Opin Chem Biol. 2020 Jun.

Abstract

Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD®-Soluble and TLD-1433, which have ideal photophysical properties to act as PDT PSs. We highlight the important role played by the metal ions in the PS for PDT activity.

Keywords: Bioinorganic chemistry; Medicinal inorganic chemistry; Metals in medicine; Photodynamic therapy; Photosensitizer.

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Conflict of interest statement

Conflict of interest statement Theralase licenses the exclusive worldwide rights for TLD-1433 and its associated PDCs.

Figures

Figure 1.
Figure 1.
Structures of PSs approved or in clinical studies for oncologic PDT
See this image and copyright information in PMC

References

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