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. 2019 Nov 1;20(11):3429-3435.
doi: 10.31557/APJCP.2019.20.11.3429.

Characterization of High-risk Oncogenic Human Papillomavirus Genotypes in Histologically Confirmed Ear, Nose and Throat (Ent) Cancers in Burkina Faso

Maïmouna Ilboudo  1   2 , Théodora Mahoukèdè Zohoncon  1   2 , Esther Mah Alima Traore  1   2 , Ina Marie Angèle Traore  1   2 , Ali Kande  1   2 , Florencia W Djigma  1   2 , Dorcas Obiri-Yeboah  3 , Yvette Marie Chantal Gyebre  4 , Jacques Simpore  1   2
Affiliations

Characterization of High-risk Oncogenic Human Papillomavirus Genotypes in Histologically Confirmed Ear, Nose and Throat (Ent) Cancers in Burkina Faso

Maïmouna Ilboudo et al. Asian Pac J Cancer Prev. .

Abstract

Background: High-risk human papillomavirus (HPV-HR) infections are responsible for 99.99% of cervico-uterine cancers and 50% of carcinomas of the oropharynx.

Objective: To characterize high-risk HPV genotypes (HPV-HR) in histologically confirmed ear, nose and throat (ENT) cancers in Ouagadougou.

Methods: One hundred and twenty-eight archived tissues from the ENT sphere, obtained over the last ten years (2007 to 2017) and histologically diagnosed in anatomy and pathology-cytology laboratories in Ouagadougou were included. These tissues were dewaxed with xylene; HPV DNA extraction was performed and HPV-HR were researched by real-time multiplex PCR.

Results: Among the fourteen HPV-HR genotypes tested for, seven were identified. The prevalence of HPV-HR infection was 15.6%. The most common genotypes were: HPV56 (45%) and HPV33 (20%). Squamous cell carcinomas accounted for 75% of cases, followed by lymphomas for 10%. The age range was between 5 and 80 years.

Conclusion: The results show the involvement of a diversity of HPV-HR genotypes and a high frequency of HPV56 and HPV33 in ENT cancers in Ouagadougou, Burkina Faso. The appropriate HPV vaccination will considerably reduce the number of these cancers.<br />.

Keywords: (high-risk HPV; Burkina Faso; Carcinoma; ENT; Real-Time PCR.

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Figures

Figure 1
Figure 1
Distribution of ENT Cancer Cases by Year and Gender from 2007 to 2017
Figure 2
Figure 2
Distribution of ENT Cancer Cases by Age and Gender
Figure 3
Figure 3
Prevalence of HPV-HR Genotypes in Samples
See this image and copyright information in PMC

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