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Case Reports
. 2019 Nov;58(6):849-851.
doi: 10.1016/j.tjog.2019.09.021.

Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency

Yuya Fujibe  1 , Tasuku Mariya  2 , Masahito Mizuuchi  1 , Shinichi Ishioka  1 , Masahiro Yoshida  3 , Tsuyoshi Saito  1
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Free article
Case Reports

Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency

Yuya Fujibe et al. Taiwan J Obstet Gynecol. 2019 Nov.
Free article

Abstract

Objective: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency.

Case report: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae.

Conclusion: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks.

Keywords: Hereditary antithrombin deficiency; Pregnancy; Prophylaxis; Recombinant human antithrombin; Venous thromboembolism.

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