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Review
. 2020 Sep;50(9):1038-1047.
doi: 10.1111/imj.14709.

Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management

Tony Dazhong Huang  1   2 , Jason Behary  1   2 , Amany Zekry  1   2
Affiliations
Review

Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management

Tony Dazhong Huang et al. Intern Med J. 2020 Sep.

Abstract

Due to the rising prevalence of obesity and type II diabetes mellitus, non-alcoholic fatty liver disease is becoming the leading cause of chronic liver disease in the Western world. In some patients, simple steatosis can result in non-alcoholic steatohepatitis which over time can lead to liver cirrhosis and its associated sequelae, including hepatocellular carcinoma. Early identification and management of patients at risk with intensive dietary and lifestyle modification are essential to prevent the development of advanced liver disease and its complications. In this review, we will discuss the epidemiology of non-alcoholic fatty liver disease, pathogenesis, diagnosis, management and surveillance strategies to offset the morbidity and mortality of this disease, as well as liver and non-liver-related complications.

Keywords: hepatocellular carcinoma; liver cirrhosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis.

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References

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    1. Organización para la Cooperación y el Desarrollo Económicos. Obesity Update 2017. OECD Update Report 13, 2017, 331-41.

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