Clinical application of photodynamic therapy for malignant airway tumors in China

Abstract

With the development of interventional pulmonology, photodynamic therapy (PDT) is gradually being used in the treatment of respiratory malignant tumors because of its low level of trauma, high specificity, and compatibility with traditional or common therapies. However, at present, the data of clinical evidence-based medicine for PDT applied in central airway tumors is very limited, and derives mainly from case reports or series of case studies which lack consensus on clinical diagnosis and treatment. In order to further disseminate China's experience, the Tumor Photodynamic Therapy Committee of China Anti-Cancer Association and the World Endoscopy Association-Respiratory Endoscopy Association invited experts from relevant fields to form an expert committee. After several rounds of discussion and revision by this committee, and following a vote, the consensus was formulated for reference by physicians in respiratory, oncology and other related disciplines to refer to the practice of tumor photodynamic therapy.

Keywords: Guidelines; photodynamic therapy; respiratory tumors.

Figure 1

Photodynamic laser therapeutic instrument (PDT630, Guilin Xingda photoelectric medical equipment Co., Ltd.).

Figure 2

Various optical fibers. (a) Flat optical fiber. (b) Cylindrical optical fiber. (c) Spherical optical fiber.

Figure 3

Recommended photodynamic therapy procedures. (a) Evaluate tumor focus and develop treatment plan using CT and bronchoscopy. (b) Direct optical fiber irradiation is performedafter intravenous injection of photosensitizer for 40 h. (c) Secondary irradiation can be performed 72 hours afterinjection of photosensitizer. (d) Application of general anesthesia is recommended during whole treatment. (e) Remove necrotic tissue before each irradiation. (f) Bronchoscopy needs to be reexamined 1 monthafter photodynamic therapy.