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Observational Study
. 2019 Jan-Dec:13:1753466619888128.
doi: 10.1177/1753466619888128.

Satisfaction with chronic obstructive pulmonary disease treatment: results from a multicenter, observational study

Marco Contoli  1 , Paola Rogliani  2 , Fabiano Di Marco  3 , Fulvio Braido  4 , Angelo G Corsico  5 , Christian A Amici  6 , Roberto Piro  7 , Riccardo Sarzani  8 , Patrizia Lessi  9 , Carla Scognamillo  9 , Nicola Scichilone  10 , Pierachille Santus  11 ; SAT Study Group
Collaborators, Affiliations
Observational Study

Satisfaction with chronic obstructive pulmonary disease treatment: results from a multicenter, observational study

Marco Contoli et al. Ther Adv Respir Dis. 2019 Jan-Dec.

Abstract

Background: Understanding the level of patients' satisfaction with treatment and its determinants have the potential to impact therapeutic management and clinical outcome in chronic conditions such as chronic obstructive pulmonary disease (COPD).

Methods: A national, multicenter, longitudinal, observational study of COPD from 20 Italian pulmonary centers to explore patients' satisfaction to treatment [assessed by the Treatment Satisfaction Questionnaire, 9 items (TSQM-9)] and association with clinical parameters [including dyspnea score, COPD Assessment Test (CAT) score, exacerbation rate], adherence to treatment [Morisky Medication-Taking Adherence Scale (MMAS-4)], illness perception [evaluated by Brief Illness Perception Questionnaire (B-IPQ)] in a 1-year follow up.

Results: A total of 401 COPD patients were enrolled [69.4% group B Global Initiative for COPD (GOLD), considering 366 patients with available GOLD 2017 classification at enrollment]. At enrollment, satisfaction with treatment was moderate, being TSQM-9 mean scores for effectiveness 64.2 [95% confidence interval (CI) 62.5-65.9], for convenience 75.8 (95% CI 74.2-77.3), and for global satisfaction 65.7 (95% CI 64.0-67.4). Global satisfaction was negatively associated with disease perception (β = -0.4709, p < 0.0001), and grade of dyspnea (β = -4.2564, p = 0.009). Satisfaction with treatment was lower in patients with poor compared with optimal adherence to treatment (β = -4.5608, p = 0.002). Changes in inhalation regimens during follow up did not modify the satisfaction with treatment.

Conclusions: The results of this real-life study showed that the patients' satisfaction with treatments is only moderate in COPD. A high grade of patients' satisfaction is associated mainly with a low perception of the disease, high adherence to treatment and lower level of dyspnea.

Trial registration: Clinicaltrials.gov identifier: NCT02689492 The reviews of this paper are available via the supplemental material section.

Keywords: COPD; adherence; treatment satisfaction.

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Conflict of interest statement

Conflict of interest statement: The following authors report personal fees for scientific consultation from Boehringer Ingelheim related to the study: FB, MC, PS, AGC, FDM, PR, NS.

FB has received honoraria for lectures at national and international meetings from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi Farmaceutici, Dompè, Guidotti/Malesci, GlaxoSmith-Kline, Menarini, Novartis, Lallemand Pharma, Biophutura, Levante Pharma, Merck Sharp & Dohme and Zambon; he has served as consultant for AstraZeneca, Chiesi Farmaceutici, Novartis, Glaxo Smith Kline, Boehringer Ingelheim, Guidotti/MalesciZambon, Csl Behring.

MC reports grants for research from AstraZeneca and Chiesi, and reports personal fees for scientific consultations and/or lectures at national and international meetings from Chiesi, Novartis, AstraZeneca, Glaxo Smith Kline, Boehringer Ingelheim, Menarini, Zambon, outside the submitted work.

FDM has received honoraria for lectures at national and international meetings from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi Farmaceutici, Dompe, Guidotti/Malesci, GlaxoSmithKline, Menarini, Novartis, and Zambon; he has served as consultant for AstraZeneca, Chiesi Farmaceutici, Novartis, and Zambon; he has received financial support for research from Novartis, and Boehringer Ingelheim.

PR has participated as a lecturer, speaker, and advisor in scientific meetings and courses under the sponsorship of Almirall, AstraZeneca, Biofutura, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Menarini Group, Mundipharma, and Novartis; her department has received funding from Almirall, Boehringer Ingelheim, Chiesi, Novartis, and Zambon; she has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PL and CS are employees of Boehringer Ingelheim Italy.

CAA is employee for MediNeos Observational Research, Modena, Italy. MediNeos Observational Research received payment from Boehringer Ingelheim Italy for the following activities related to the submitted work: scientific support, clinical operations, data management, statistical analysis, and manuscript preparation.

RP and RS do not report any conflicts of interest.

Figures

Figure 1.
Figure 1.
Percentage scores related to effectiveness, convenience, and global satisfaction domains of the TSQM-9 assessments at enrollment, at the 6-month, and 12-month visits. No clinically relevant difference is evident in the TSQM-9 scores during the study period. The satisfaction to treatment in these patients is moderate. The bar represents the standard deviation. TSQM-9, Treatment Satisfaction Questionnaire, 9 items.
See this image and copyright information in PMC

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