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Review
. 2020 Feb;40(1):1-14.
doi: 10.1016/j.iac.2019.09.009. Epub 2019 Nov 6.

Mechanisms of Subcutaneous and Sublingual Aeroallergen Immunotherapy: What Is New?

Zsolt István Komlósi  1 , Nóra Kovács  2 , Milena Sokolowska  3 , Willem van de Veen  3 , Mübeccel Akdis  3 , Cezmi A Akdis  3
Affiliations
Free article
Review

Mechanisms of Subcutaneous and Sublingual Aeroallergen Immunotherapy: What Is New?

Zsolt István Komlósi et al. Immunol Allergy Clin North Am. 2020 Feb.
Free article

Abstract

Allergen immunotherapy (AIT) is considered to be the only treatment option with the promise of healing and induction of long-lasting allergen tolerance, persisting even after discontinuation of therapy. Despite a more than 100-year-long history, still only a minority of patients are being treated with AIT. Substantial developments took place in the last decade to overcome problems in standardization, efficacy, safety, high costs, long duration of treatment; and new guidelines have also been implemented. Major advancements in the understanding of AIT mechanisms with the focus on recent findings of subcutaneous and sublingual AIT have been summarized.

Keywords: Aeroallergen; Allergen immunotherapy; Allergy; Breg cells; Innate lymphoid cells; Subcutaneous allergen immunotherapy; Sublingual allergen immunotherapy; Treg cells.

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