Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2019 Nov;49(5):371-375.
doi: 10.1016/j.neucli.2019.10.002. Epub 2019 Nov 21.

Twice-daily neuronavigated intermittent theta burst stimulation for bipolar depression: A Randomized Sham-Controlled Pilot Study

Samuel Bulteau  1 , Lysianne Beynel  2 , Christian Marendaz  3 , Gaelle Dall'Igna  4 , Morgane Peré  5 , Sylvain Harquel  3 , Alan Chauvin  3 , Nathalie Guyader  6 , Anne Sauvaget  7 , Jean-Marie Vanelle  8 , Mircea Polosan  4 , Thierry Bougerol  4 , Jerôme Brunelin  9 , David Szekely  10
Affiliations
Randomized Controlled Trial

Twice-daily neuronavigated intermittent theta burst stimulation for bipolar depression: A Randomized Sham-Controlled Pilot Study

Samuel Bulteau et al. Neurophysiol Clin. 2019 Nov.

Abstract

The safety and efficacy of neuronavigated intermittent theta burst stimulation (iTBS) in patients with bipolar depression has not yet been investigated. We hypothesized the superiority of active iTBS over sham. Twenty-six patients were randomly allocated to receive either active (n=12) or sham (n=14) iTBS. Response and remission rates according to changes in depression MADRS score were high following active iTBS (72% and 42% for response and remission rates, respectively), but no significant difference was found after sham stimulation (42%and 25%). No adverse events were observed. This study revealed the safety and tolerability of twice daily iTBS in patients with bipolar depression. Larger controlled studies are warranted to prove iTBS superiority in treatment-resistant bipolar depression.

Keywords: Bipolar depression; Dorsolateral prefrontal cortex; Neuronavigation; Randomized pilot trial; Repetitive transcranial magnetic stimulation; Resistant depression; Theta burst stimulation.

PubMed Disclaimer

Publication types