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. 2020 Mar 5:228:117696.
doi: 10.1016/j.saa.2019.117696. Epub 2019 Nov 4.

A cystine-based dual chemosensor for fluorescent-colorimetric detection of CN- and fluorescent detection of Fe3+ in aqueous media: Synthesis, spectroscopic, and DFT studies

Samaneh Ahmadi  1 , Hossein A Dabbagh  2 , Paolo Grieco  3 , Saeed Balalaie  4
Affiliations

A cystine-based dual chemosensor for fluorescent-colorimetric detection of CN- and fluorescent detection of Fe3+ in aqueous media: Synthesis, spectroscopic, and DFT studies

Samaneh Ahmadi et al. Spectrochim Acta A Mol Biomol Spectrosc. .

Abstract

A new dual-responsive chiral cystine based chemosensor, Cys(cou)2, has been designed and characterized by 1H NMR, 13C NMR, FT-IR, UV-vis as well as elemental analysis. This sensor exhibited an excellent response towards Fe3+ and CN- with high selectivity and sensitivity by fluorescence turn-off mechanism. The binding mode of Cys(cou)2 with Fe3+, and CN- was confirmed by ESI-MS, 1H NMR, and fluorescence titration and also quantum chemical calculation. These results showed that the stoichiometric ratio of Cys(cou)2-Fe3+ and Cys(cou)2-CN is 1:1 and 1:3 in DMSO/Tris aqueous buffer (1:1, v/v), respectively. The linear relationship of the Stern-Volmer plot illustrates the static quenching mechanism at different concentrations. The detection limit (LOD) and binding constant (Ka) for Fe3+ and CN- are 0.029 μM, 1.28 × 104 and 0.51 μM, 9.94 × 106, respectively. Moreover, Cys(cou)2 can act as a colorimetric sensor for CN- in DMSO with the color change from colorless to yellow.

Keywords: Amphi-ionophore; CN(−); Coumarin; DFT; Fe(3+); Fluorescence.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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