Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;50(1):10-16.
doi: 10.1002/eji.201948134. Epub 2019 Dec 3.

The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus

Hideki Ueno  1   2   3   4
Affiliations
Review

The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus

Hideki Ueno. Eur J Immunol. 2020 Jan.

Abstract

Generation of autoantibodies is a hallmark of systemic lupus erythematosus (SLE). As demonstrated in a number of lupus mouse models, recent evidence suggests that both GC and extrafollicular pathways contribute to the generation of autoantibodies also in human SLE, and that CD11c+ IgD- CD27- (double negative:DN) B cells play a central role in the latter pathway. In this mini-review, the author will first briefly summarize the features of CD11c+ DN B cells in human SLE, and discuss how the IL-12-STAT4 axis might contribute to the generation of autoantibodies in SLE. In addition, various types of CD4+ helper T cell subsets promoting the generation of autoantibodies in SLE will be described, and finally it will be discussed how these recent discoveries contribute to understanding of SLE pathogenesis and treatment of SLE patients.

Keywords: CD11c+ T-bet+ B cells; IL-12; STAT4; T-bet; systemic lupus erythematosus.

PubMed Disclaimer

References

    1. Tsokos, G. C., Systemic lupus erythematosus. N. Engl. J. Med. 2011. 365: 2110-2121.
    1. Blanco, P., Ueno, H. and Schmitt, N., T follicular helper (Tfh) cells in lupus: activation and involvement in SLE pathogenesis. Eur. J. Immunol. 2016. 46: 281-290.
    1. Arce, E., Jackson, D. G., Gill, M. A., Bennett, L. B., Banchereau, J. and Pascual, V., Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. J. Immunol. 2001. 167: 2361-2369.
    1. Jacobi, A. M., Odendahl, M., Reiter, K., Bruns, A., Burmester, G. R., Radbruch, A.,Valet, G. et al., Correlation between circulating CD27 high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthr. Rheumat. 2003. 48: 1332-1342.
    1. Grammer, A. C., Slota, R., Fischer, R., Gur, H., Girschick, H., Yarboro, C., Illei, G. G. et al., Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. J. Clin. Invest. 2003. 112: 1506-1520.

Publication types

MeSH terms