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Case Reports
. 2019 Oct 8;11(10):e5864.
doi: 10.7759/cureus.5864.

A Rare Presentation of Nodular Amyloidosis on the Lower Back

Yelena Dokic  1 , Paul Subrt  2 , Jaime Tschen  3
Affiliations
Case Reports

A Rare Presentation of Nodular Amyloidosis on the Lower Back

Yelena Dokic et al. Cureus. .

Abstract

Primary localized cutaneous amyloidosis (PLCA) occurs when amyloid is deposited only within the skin and there is no evidence of systemic involvement. Nodular amyloidosis is the rarest subtype of PLCA. It typically involves the acral regions but can sometimes present on the head and neck. The condition usually presents clinically as a single tan or yellow nodule or plaque that may appear waxy. Herein, we present a rare case of a 66-year-old man with nodular amyloidosis on the lower back.

Keywords: lichen amyloidosis; nodular amyloidosis; papular amyloidosis; primary localized cutaneous amyloidosis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A yellowish-red plaque on the lower back.
Arrow indicates plaque, 2 cm by 1 cm in size.
Figure 2
Figure 2. Homogenous amyloid material in the dermis.
Arrow indicates amyloid material. Hematoxylin-eosin stain, original magnification 100x.
Figure 3
Figure 3. Clusters of perivascular mononuclear cells.
Arrow indicates perivascular mononuclear cells. Hematoxylin-eosin stain, original magnification 200x.
Figure 4
Figure 4. Clusters of perivascular mononuclear cells.
Arrow indicates a plasma cell with an eccentric nucleus. Hematoxylin-eosin stain, original magnification 400x.
Figure 5
Figure 5. Amyloid material in the dermis.
Arrows pointing to amyloid material. Positive Congo Red stain, original magnification 200x.
Figure 6
Figure 6. Amyloid deposits birefringent under polarized light.
Arrows indicate amyloid deposits. Positive Congo Red stain with polarized light, original magnification 200x.
See this image and copyright information in PMC

References

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