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. 2019 Apr;1(2):104-112.
doi: 10.1002/acr2.1013. Epub 2019 Apr 6.

Association between Pre-Intervention Physical Activity Level and Treatment Response to Exercise Therapy in Persons with Knee Osteoarthritis - An Exploratory Study

Alison H Chang  1 , Jungwha Lee  2 , Jing Song  3 , Lori Lyn Price  4   5 , Augustine C Lee  5 , Kieran F Reid  6 , Roger A Fielding  6 , Jeffrey B Driban  5 , William C Harvey  5 , Chenchen Wang  5
Affiliations

Association between Pre-Intervention Physical Activity Level and Treatment Response to Exercise Therapy in Persons with Knee Osteoarthritis - An Exploratory Study

Alison H Chang et al. ACR Open Rheumatol. 2019 Apr.

Abstract

Objective: Examine whether pre-intervention physical activity (PA) level is associated with achieving a positive treatment response of pain and/or function improvement after a 12-week exercise intervention in participants with knee osteoarthritis (OA).

Methods: We performed a secondary analysis of a randomized, single-blind comparative effectiveness trial showing similar treatment effects between Tai Chi mind-body exercise and standard physical therapy intervention for knee OA. Baseline PA was assessed by Community Healthy Activities Model Program for Seniors (CHAMPS) Questionnaire and, in a subsample, by tri-axial accelerometers. OMERACT-OARSI dichotomous responder criteria was used for clinically meaningful improvement at follow-up. Associations between baseline self-reported PA by CHAMPS and outcomes of responders vs. non-responders (reference group) were assessed using logistic regressions, adjusting for demographic covariates. We compared objectively-measured PA by accelerometry between responders vs. non-responders using Wilcoxon tests.

Results: Our sample consisted of 166 participants with knee OA who completed both baseline and 12-week post-intervention evaluations: mean age 60.7 year (SD 10.5), BMI 32.4 kg/m2 (6.9), 119 (72%) women, and 138 (83%) OMERACT-OARSI responders. Neither time spent in total PA (OR 1.00; 95% CI 0.96, 1.03) nor time in moderate-to-vigorous (MV) PA (OR 1.01; 95% CI 0.93, 1.09) at pre-intervention were associated with being a responder. Similar findings were observed in 42 accelerometry sub-cohort participants.

Conclusion: Pre-intervention PA level (subjective report or objective measurement) was not associated with whether an individual will achieve favorable treatment outcomes after a 12-week exercise intervention, suggesting that regardless of pre-intervention PA level, individuals will likely benefit from structured exercise interventions.

Keywords: Exercise; OMERACT; Osteoarthritis; Physical Activity.

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Conflict of interest statement

CONFLICT OF INTEREST: The authors have no conflict of interest relevant to the reported work.

Figures

Figure 1
Figure 1
Outcome Measures in Rheumatoid Arthritis Clinical Trials‐Osteoarthritis Research Society International (OMERACT‐OARSI) responder criteria for defining clinically meaningful improvement at the end of exercise intervention (12 weeks).
See this image and copyright information in PMC

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