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. 2020 May;39(5):949-956.
doi: 10.1002/jum.15179. Epub 2019 Nov 25.

Two-Dimensional Shear Wave Elastography in the Assessment of Salivary Gland Involvement in Primary Sjögren's Syndrome

Serdar Arslan  1 , Mehmet Sedat Durmaz  2 , Hasan Erdogan  3 , Serpil Ergulu Esmen  4 , Bekir Turgut  5 , Mehmet Sinan Iyisoy  6
Affiliations

Two-Dimensional Shear Wave Elastography in the Assessment of Salivary Gland Involvement in Primary Sjögren's Syndrome

Serdar Arslan et al. J Ultrasound Med. 2020 May.

Abstract

Objectives: The aim of this study was to investigate the diagnostic performance of two-dimensional (2D) shear wave elastography (SWE) in the assessment of salivary gland involvement in primary Sjögren's syndrome (pSS).

Methods: Fifty-three patients with pSS and 30 healthy volunteers were included. The echogenicity of all submandibular and parotid glands was evaluated with B-mode ultrasound, and their elasticity was assessed with 2D SWE. The mean and standard deviation of the shear wave speed and elasticity modes on 2D SWE were calculated.

Results: The mean shear wave speed and elasticity mode values for the submandibular and parotid glands were significantly higher in the patients with pSS (P < .05). The mean elasticity of the shear wave speed mode was best able to differentiate the parotid glands of patients with pSS from those of healthy volunteers at a cutoff value of 2.48 m/s, whereas the mean elasticity of the elasticity mode was best able to differentiate the submandibular glands of patients with pSS from those of healthy volunteers at a cutoff value of 21 kPa.

Conclusions: Two-dimensional SWE is an effective technique for assessment of the parenchyma of the salivary glands in patients with pSS and predicts interstitial fibrosis and the severity of histologic damage.

Keywords: Sjögren's syndrome; salivary glands; shear wave elastography; ultrasound.

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