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. 2020 Apr;22(2):169-177.
doi: 10.1177/1099800419889192. Epub 2019 Nov 25.

The Relationships of High-Sensitivity C-Reactive Protein and Homocysteine Levels With Disease Activity, Damage Accrual, and Cardiovascular Risk in Systemic Lupus Erythematosus

Gabriela Pocovi-Gerardino  1   2 , Maria Correa-Rodríguez  1   3 , José-Luis Callejas Rubio  4 , Raquel Ríos Fernández  4 , María Martín Amada  5 , María-Gracia Cruz Caparros  6 , Blanca Rueda-Medina  1   2 , Norberto Ortego-Centeno  3   4
Affiliations

The Relationships of High-Sensitivity C-Reactive Protein and Homocysteine Levels With Disease Activity, Damage Accrual, and Cardiovascular Risk in Systemic Lupus Erythematosus

Gabriela Pocovi-Gerardino et al. Biol Res Nurs. 2020 Apr.

Abstract

Results: hs-CRP correlated significantly with SLEDAI-2K (p = .036), SDI (p = .00), anti-dsDNA titers (p = .034), diabetes (p = .005), and obesity (p = .027). hs-CRP and Hcy correlated with triglyceride (TG) levels (p = .032 and p < .001, respectively), TG/high-density lipoprotein cholesterol index (p = .020 and p = .001, respectively), and atherogenic index of plasma (p = .006 and p = .016, respectively). hs-CRP levels >3 mg/L correlated with SDI score (p = .012) and several CVD risk factors.

Discussion: Findings suggest SLE patients with elevated hs-CRP and/or Hcy have a higher prevalence of CVD risk factors.

Keywords: C-reactive protein; autoimmune; cardiovascular; homocysteine; inflammation; lupus.

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