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Comment
. 2020 Jan 2;130(1):68-70.
doi: 10.1172/JCI133119.

Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs

Corinna A Kulicke  1 , Deborah A Lewinsohn  1 , David M Lewinsohn  1   2
Affiliations
Comment

Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs

Corinna A Kulicke et al. J Clin Invest. .

Abstract

Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and γδ T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis-infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of γδ T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of high-throughput analysis of the TCR repertoire directly from infected tissue. The findings contribute to our understanding of tuberculosis control and have implications for the development of both therapeutic and vaccination strategies.

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Conflict of interest statement

Conflict of interest: DAL and DML are co-inventors on patents that protect the development of tuberculosis antigens recognized by human CD8+ T cells for diagnostic and vaccine use. These are: US8961989B2, Methods for producing an immune response to tuberculosis; US8053181B2, Methods for detecting a Mycobacterium tuberculosis infection; US20150273039A1, Compositions comprising soluble HLA/M. Tuberculosis-specific ligand complexes and methods of production and use thereof; and US20180273536A1, Small molecules that bind mr1.

Figures

Figure 1
Figure 1. Models of local enrichment of T cell clones.
(A) Antigen-specific T cell clones undergo antigen-driven clonal expansion and are specifically recruited to the infected tissue. (B) A subset of the circulating T cell repertoire stochastically seeds to the tissue and locally present T cell clones expand in response to infection in an antigen-driven or nonspecific manner. LN, lymph node.
See this image and copyright information in PMC

Comment on

References

    1. Van Rhijn I, Moody DB. Donor unrestricted T cells: a shared human T cell Response. J Immunol. 2015;195(5):1927–1932. doi: 10.4049/jimmunol.1500943. - DOI - PMC - PubMed
    1. Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB. The burgeoning family of unconventional T cells. Nat Immunol. 2015;16(11):1114–1123. doi: 10.1038/ni.3298. - DOI - PubMed
    1. Yang Y, et al. A structural change in butyrophilin upon phosphoantigen binding underlies phosphoantigen-mediated Vγ9Vδ2 T cell activation. Immunity. 2019;50(4):1043–1053.e5. doi: 10.1016/j.immuni.2019.02.016. - DOI - PubMed
    1. Fan X, Rudensky AY. Hallmarks of tissue-resident lymphocytes. Cell. 2016;164(6):1198–1211. doi: 10.1016/j.cell.2016.02.048. - DOI - PMC - PubMed
    1. Joosten SA, et al. Harnessing donor unrestricted T-cells for new vaccines against tuberculosis. Vaccine. 2019;37(23):3022–3030. doi: 10.1016/j.vaccine.2019.04.050. - DOI - PMC - PubMed

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