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Review
. 2019 Dec;32(12):550-552.
doi: 10.1097/01.ASW.0000604176.47082.60.

Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report

Qiannan Zhao  1 , Yuanyuan Ma, Yuquan Lu, Yuan Chai, Yuemin Zhou
Affiliations
Review

Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report

Qiannan Zhao et al. Adv Skin Wound Care. 2019 Dec.

Abstract

Hydroxyurea is an oral medication associated with painful, nonhealing ulcers, for which there is no effective treatment but permanent discontinuation of hydroxyurea. The authors present a case of leg ulcers that likely occurred as a result of hydroxyurea use in a patient with essential thrombocythemia. Topical treatment with allogeneic platelet-rich plasma and artificial dermis completely healed the leg ulcers without hydroxyurea cessation.

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Figures

Figure 1.
Figure 1.
HISTOLOGY ANALYSIS OF SKIN BIOPSY Presentation shows epidermal atrophy and perivascular lymphocytic infiltrates in the corium layer with infiltration by plasma cells and neutrophils.
Figure 2.
Figure 2.
CLINICAL PRESENTATION OF ULCERS BEFORE AND AFTER TREATMENT A0, B0, Two chronic lower extremity ulcers were observed on the left lower limb and left foot in the initial presentation. A1, B1, Significant improvements in the skin lesions were observed after the fourth treatment. A2, B2, Good cosmetic and therapeutic outcomes were observed 1 month later.
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