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. 2019 Nov 13;8(11):1960.
doi: 10.3390/jcm8111960.

Incidence and Risk Factors for Tractional Macular Detachment after Anti-Vascular Endothelial Growth Factor Agent Pretreatment before Vitrectomy for Complicated Proliferative Diabetic Retinopathy

Andrea Russo  1 , Antonio Longo  1 , Teresio Avitabile  1 , Vincenza Bonfiglio  1 , Matteo Fallico  1 , Francesco Boscia  2 , Claudio Furino  3 , Salvatore Cillino  4 , Mario Toro  1   5 , Robert Rejdak  5 , Katarzyna Nowomiejska  5 , Michele Reibaldi  1
Affiliations

Incidence and Risk Factors for Tractional Macular Detachment after Anti-Vascular Endothelial Growth Factor Agent Pretreatment before Vitrectomy for Complicated Proliferative Diabetic Retinopathy

Andrea Russo et al. J Clin Med. .

Abstract

The study's purpose was to determine the incidence, risk factors, and outcomes of tractional macular detachment after anti-vascular endothelial growth factor (VEGF) pretreatment before vitrectomy for complicated proliferative diabetic retinopathy. Patients who underwent primary vitrectomy for complicated proliferative diabetic retinopathy, from January 2012 to 31 December 2018, were enrolled. Ophthalmic and pre-operative data were extracted from electronic record systems. All eyes with a valuable Optical Coherence Tomography (OCT)performed within 5 days before injection of anti-VEGF and on the day of vitrectomy were included. Multivariable logistic regression showed that significant risk factors for developing tractional macular detachment included days between anti-VEGF and vitrectomy (OR, 0.71 [95% CI 0.65-0.76]; p < 0.001), vitreous hemorrhage (OR, 0.23 [95% CI 0.11-0.49]; p < 0.001), and age (OR, 1.05 [95% CI 1.02-1.08]; p < 0.001). Decision-tree analysis showed that the stronger predictors of tractional macular detachment were the time between anti-VEGF injection and vitrectomy (p < 0.001). Secondary predictors were the presence of vitreous hemorrhage (p = 0.012) in eyes that underwent vitrectomy between 6 and 10 days after anti-VEGF injection and younger age (p = 0.031) in eyes that underwent vitrectomy 10 days after anti-VEGF injection. Tractional macular detachment occurs in 10% of eyes after anti-VEGF injection, the main risk factors being days between anti-VEGF injection and vitrectomy, vitreous hemorrhage, and age.

Keywords: anti-VEGF; proliferative diabetic retinopathy; tractional macular detachment; vitrectomy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Recruitment flowchart.
Figure 2
Figure 2
Decision-tree algorithm of the variables associated with tractional macular detachment.
See this image and copyright information in PMC

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