[Pharmacogenetics for patient care in France: A discipline that evolves!]

Abstract

Pharmacogenetics, which concepts are known for a long time, is entering a new period at least as far as its practical applications for patients are concerned. In recent years there have been more and more initiatives to promote widespread dissemination, and health authorities are increasingly incorporating these concepts into drug labels. In France, the national network of pharmacogenetics (RNPGx) works to promote these activities, both with health actors (biologists, clinicians) and health authorities. This article reviews the current situation in France and the milestones of the year 2018. It highlights recent advances in this field, in terms of currently recommended analyses, sharing of information or technological developments, and the prospects for future developments in the near future from targeted pharmacogenetics to eventually preemptive approaches.

Keywords: Drug label; Dépistage pré-thérapeutique; Ethics; Next generation sequençing; Pharmacogenetics; Pharmacogénétique; Pretherapeutic screening; Réseau national de pharmacogénétique; Résumé des caractéristiques du produit; Séquençage à haut débit; Éthique.