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Comment
. 2020 Feb;45(2):93-95.
doi: 10.1016/j.tibs.2019.11.002. Epub 2019 Nov 22.

The Brain Epigenome Goes Drunk: Alcohol Consumption Alters Histone Acetylation and Transcriptome

Irene de Diego  1 , Annika Müller-Eigner  1 , Shahaf Peleg  2
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The Brain Epigenome Goes Drunk: Alcohol Consumption Alters Histone Acetylation and Transcriptome

Irene de Diego et al. Trends Biochem Sci. 2020 Feb.

Abstract

Recent studies demonstrated that alcohol consumption can induce epigenetic changes in the brain, although the exact mechanism underlying such changes remained unclear. Now, a report by Mews et al. shows a direct link between alcohol consumption and histone acetylation changes in the brain, which are mediated by the neuronal acetyl-CoA synthase, ACSS2.

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  • Alcohol metabolism contributes to brain histone acetylation.
    Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, Alexander DC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL. Mews P, et al. Nature. 2019 Oct;574(7780):717-721. doi: 10.1038/s41586-019-1700-7. Epub 2019 Oct 23. Nature. 2019. PMID: 31645761 Free PMC article.

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