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Comment
. 2020 Jan;31(1):1-2.
doi: 10.1016/j.tem.2019.11.002. Epub 2019 Nov 22.

A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus

Kaitlin Kiernan  1 , Nancie J MacIver  2
Affiliations
Comment

A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus

Kaitlin Kiernan et al. Trends Endocrinol Metab. 2020 Jan.

Abstract

In their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a combination of increased environmental long-chain fatty acid metabolites coupled with decreased fatty acid oxidation.

Keywords: Th17; fatty acid oxidation; metabolism; obesity; type 2 diabetes.

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