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Review
. 2020 Feb 24;38(9):2250-2257.
doi: 10.1016/j.vaccine.2019.10.046. Epub 2019 Nov 22.

Updates on immunologic correlates of vaccine-induced protection

Stanley A Plotkin  1
Affiliations
Review

Updates on immunologic correlates of vaccine-induced protection

Stanley A Plotkin. Vaccine. .

Abstract

Correlates of protection (CoPs) are increasingly important in the development and licensure of vaccines. Although the study of CoPs was initially directed at identifying a single immune function that could explain vaccine efficacy, it has become increasingly clear that there are often multiple functions responsible for efficacy. This review is meant to supplement prior articles on the subject, illustrating both simple and complex CoPs.

Keywords: Antibodies; Cell mediated immunity; Correlates.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [The author consults for vaccine manufacturers including Glaxo, Merck, Pfizer and Sanofi.].

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