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. 2020 Mar;40(3):522-529.
doi: 10.1038/s41372-019-0562-z. Epub 2019 Nov 25.

Is there a role for therapeutic hypothermia administration in term infants with mild neonatal encephalopathy?

Laura Perretta  1 , Rachel Reed  1 , Gail Ross  1 , Jeffrey Perlman  2
Affiliations

Is there a role for therapeutic hypothermia administration in term infants with mild neonatal encephalopathy?

Laura Perretta et al. J Perinatol. 2020 Mar.

Abstract

Objective: Identifying term infants presenting with early mild neonatal encephalopathy (NE) as candidates for therapeutic hypothermia (TH) remains unclear. Study objectives were to characterize the neonatal clinical, magnetic resonance imaging (MRI), and longer-term outcome in infants with mild NE treated with TH.

Study design: Retrospective cohort study of infants admitted with mild or moderate NE treated with TH. Enrollment criteria included a sentinel event, severe acidosis, DR interventions, and low Apgar scores.

Results: Infants with mild (n = 11) and moderate NE (n = 37) received TH. Mild NE findings included hyperalertness (64%), hypotonia (73%), high level sensory response (91%); 64% progressed to moderate NE. Infants with mild vs. moderate NE had less severe MRI changes (0 vs. 16%) and no cerebral palsy (CP) (0 vs. 13%).

Conclusions: Outcomes were favorable with mild NE whereas four infants with moderate NE developed CP. A potential role for TH in this population requires further study.

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References

    1. Chalak L, Latremouille S, Mir I, Sánchez PJ, Sant’Anna G. A review of the conundrum of mild hypoxic-ischemic encephalopathy: current challenges and moving forward. Early Hum Dev. 2018;120:88–94. - DOI
    1. El-Dib M, et al. Should therapeutic hypothermia be offered to babies with mild encephalopathy in the first 6 h after birth? Pediatr Res. 2019;85:442–8. - DOI
    1. Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976;33:696–705. - DOI
    1. Volpe J. J. Neurology of the newborn. 6th ed. Philadelphia, PA: Elsevier; 2018.
    1. Finer NN, Robertson CM, Peters KL, Coward JH. Factors affecting outcome in hypoxic-ischemic encephalopathy in term infants. Am J Dis Child. 1983;137:21–5. - PubMed

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