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. 2019 Dec;3(12):1731-1742.
doi: 10.1038/s41559-019-1044-6. Epub 2019 Nov 25.

Sex-dependent dominance maintains migration supergene in rainbow trout

Devon E Pearse #  1 , Nicola J Barson #  2 , Torfinn Nome  2 , Guangtu Gao  3 , Matthew A Campbell  4 , Alicia Abadía-Cardoso  5 , Eric C Anderson  6 , David E Rundio  6 , Thomas H Williams  6 , Kerry A Naish  7 , Thomas Moen  8 , Sixin Liu  3 , Matthew Kent  2 , Michel Moser  2 , David R Minkley  9 , Eric B Rondeau  9 , Marine S O Brieuc  7 , Simen Rød Sandve  2 , Michael R Miller  10 , Lucydalila Cedillo  10 , Kobi Baruch  11 , Alvaro G Hernandez  12 , Gil Ben-Zvi  11 , Doron Shem-Tov  11 , Omer Barad  11 , Kirill Kuzishchin  13 , John Carlos Garza  6 , Steven T Lindley  6 , Ben F Koop  9 , Gary H Thorgaard  14 , Yniv Palti  15 , Sigbjørn Lien  16
Affiliations

Sex-dependent dominance maintains migration supergene in rainbow trout

Devon E Pearse et al. Nat Ecol Evol. 2019 Dec.

Erratum in

  • Publisher Correction: Sex-dependent dominance maintains migration supergene in rainbow trout.
    Pearse DE, Barson NJ, Nome T, Gao G, Campbell MA, Abadía-Cardoso A, Anderson EC, Rundio DE, Williams TH, Naish KA, Moen T, Liu S, Kent M, Moser M, Minkley DR, Rondeau EB, Brieuc MSO, Sandve SR, Miller MR, Cedillo L, Baruch K, Hernandez AG, Ben-Zvi G, Shem-Tov D, Barad O, Kuzishchin K, Garza JC, Lindley ST, Koop BF, Thorgaard GH, Palti Y, Lien S. Pearse DE, et al. Nat Ecol Evol. 2020 Jan;4(1):170. doi: 10.1038/s41559-019-1076-y. Nat Ecol Evol. 2020. PMID: 31819240

Abstract

Males and females often differ in their fitness optima for shared traits that have a shared genetic basis, leading to sexual conflict. Morphologically differentiated sex chromosomes can resolve this conflict and protect sexually antagonistic variation, but they accumulate deleterious mutations. However, how sexual conflict is resolved in species that lack differentiated sex chromosomes is largely unknown. Here we present a chromosome-anchored genome assembly for rainbow trout (Oncorhynchus mykiss) and characterize a 55-Mb double-inversion supergene that mediates sex-specific migratory tendency through sex-dependent dominance reversal, an alternative mechanism for resolving sexual conflict. The double inversion contains key photosensory, circadian rhythm, adiposity and sex-related genes and displays a latitudinal frequency cline, indicating environmentally dependent selection. Our results show sex-dependent dominance reversal across a large autosomal supergene, a mechanism for sexual conflict resolution capable of protecting sexually antagonistic variation while avoiding the homozygous lethality and deleterious mutations associated with typical heteromorphic sex chromosomes.

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References

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