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. 2020 Jan;5(1):27-33.
doi: 10.1038/s41564-019-0609-0. Epub 2019 Nov 25.

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Masaki Imai #  1 , Makoto Yamashita #  2 , Yuko Sakai-Tagawa #  2 , Kiyoko Iwatsuki-Horimoto #  2 , Maki Kiso  2 , Jurika Murakami  2 , Atsuhiro Yasuhara  2 , Kosuke Takada  2 , Mutsumi Ito  2 , Noriko Nakajima  3 , Kenta Takahashi  3 , Tiago J S Lopes  2   4 , Jayeeta Dutta  5 , Zenab Khan  5 , Divya Kriti  5 , Harm van Bakel  5 , Akifumi Tokita  6   7 , Haruhisa Hagiwara  7   8 , Naomi Izumida  7   9 , Haruo Kuroki  10 , Tamon Nishino  7   11 , Noriyuki Wada  7   12 , Michiko Koga  13 , Eisuke Adachi  14 , Daisuke Jubishi  2   15 , Hideki Hasegawa  3   16 , Yoshihiro Kawaoka  17   18   19
Affiliations

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Masaki Imai et al. Nat Microbiol. 2020 Jan.

Abstract

Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility to baloxavir marboxil-from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.

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Comment in

  • Emerging antiviral resistance.
    Kormuth KA, Lakdawala SS. Kormuth KA, et al. Nat Microbiol. 2020 Jan;5(1):4-5. doi: 10.1038/s41564-019-0639-7. Nat Microbiol. 2020. PMID: 31857727 No abstract available.

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