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Review
. 2020 Mar;52(3):497-503.
doi: 10.1007/s11255-019-02335-7. Epub 2019 Nov 25.

Ferroptosis and kidney diseases

Shumei Tang  1 , Xiangcheng Xiao  2
Affiliations
Review

Ferroptosis and kidney diseases

Shumei Tang et al. Int Urol Nephrol. 2020 Mar.

Abstract

Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis recently has been shown to have implications in diverse kidney diseases, such as acute kidney injury, polycystic kidney disease and renal cell carcinoma. This review summarizes current research on ferroptosis, its underlying mechanisms and its role in the progression of different kidney diseases to provide more information regarding treatment and prevention of these destructive diseases.

Keywords: Acute kidney injury; Ferroptosis; Kidney disease; Polycystic kidney; Renal cell carcinoma.

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