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Editorial
. 2019 Dec;39(12):2454-2456.
doi: 10.1161/ATVBAHA.119.313531. Epub 2019 Nov 26.

Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?

David X Zhang  1 , David D Gutterman  1
Affiliations
Editorial

Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?

David X Zhang et al. Arterioscler Thromb Vasc Biol. 2019 Dec.
No abstract available

Keywords: Editorial; cell differentiation; coronary artery disease; growth and development; muscle; potassium channels; smooth, vascular.

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Figures

Figure.
Figure.. The proposed contribution of KV1.5 and KV1.3 channels to vascular smooth muscle cell (VSMC) proliferation.
Left: Kv1.5 channel is a myocardin-regulated, VSMC contractile marker and inhibits VSMC proliferation by hampering KV1.3-induced proliferative signaling. Right: upon stimulation of growth factors in combination with vascular injury or disease, the myocardin-dependent down-regulation of KV1.5 reveals KV1.3 as the main KV1 channels, which consequently leads to the activation of proliferation pathways.
See this image and copyright information in PMC

Comment on

References

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